Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles

Abstract Background Breast cancer is one of the most challenging cancers among women which considered lethal to this date. From time that has been discovered, finding best therapeutic method still an ongoing process. As a novel method, nanomedicine brought vast number materials could versatilely be used as drug carrier. The purpose study develop black pomegranate peel extract loaded with chitosan-coated magnetic nanoparticles treat breast cells. Results morphology and size distribution studied by dynamic light scattering, atomic force microscopy, scanning, transitional electron microscopy showed spherical shape their promising range. Studies Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometer, zeta sizer confirmed synthesis, substantial crystallinity, potential nanoparticles, satisfactory stability. DPPH assay revealed obtained 60% free radical scavenging activity. cytotoxicity studies MTT LDH carried out on NIH/3T3, MBA-MB-231, 4T1 cells had no significant However, drug-loaded significantly eradicate cancerous more efficiency comparing drug. Furthermore, toxic effect normal Conclusion Owing results achieved from study, are compatible for treatment potentially further in vivo studies.